Using multiple interdependency to separate functional from phylogenetic correlations in protein alignments
نویسندگان
چکیده
منابع مشابه
Using multiple interdependency to separate functional from phylogenetic correlations in protein alignments
MOTIVATION Multiple sequence alignments of homologous proteins are useful for inferring their phylogenetic history and to reveal functionally important regions in the proteins. Functional constraints may lead to co-variation of two or more amino acids in the sequence, such that a substitution at one site is accompanied by compensatory substitutions at another site. It is not sufficient to find ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2003
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg072